动物及人兽共患传染病国际学术研讨会
　　International Symposium on Animal and Zoonotic Infectious Diseases

　　西北农林科技大学动物重大疫病病原感染和致病机制团队
　　Animal Infectious Disease Research Team, Northwest A&F University

　　英国利物浦大学感染与全球健康研究所
　　Institute of Infection and Global Health, University of Liverpool, UK

　　日期及地点：2018年10月12日，西北农林科技大学动物医学院4129会议室
　　Date and Place: October 12, 2018, College of Veterinary Medicine, Northwest A&F University

　　主旨演讲/Keynote Speech

　　10月12日/October 12

　　报告人简介/Speakers Biography

　　Prof. Julian Hiscox is Chair in Infection and Global Health at the University of Liverpool where he leads an internationally focused research group. He is also a visiting Professor at Northwest A&F University (China) and the Singapore Immunology Network at A*STAR (Singapore).Prior to joining the University of Liverpool he held academic positions at the University of Leeds and Reading. He graduated from University College London with a Degree in Genetics in 1991 and a PhD from the Institute for Animal Health (now the Pirbright Institute) in 1994. He conducted post-doctoral research at the University of Alabama at Birmingham (USA).His work has focused on defining virus/host interactions and over the years he has studied coronaviruses (IBV, SARS, MERS), arteriviruses (PRRSV) and for the past ten years negative strand RNA viruses (Ebola virus and human respiratory syncytial virus).Recently, his laboratory led the Ebola virus sequencing effort for the European Mobile Laboratory as part of the response to the Ebola virus crisis in West Africa and was featured in three publications in Nature. His work is funded by the National Institute of Health Research, Public Health England, Defence Science Technology Laboratory, Food and Drug Administration (USA) and the Defence Advanced Research Project Agency (USA).

　　Dr. David Matthews is an expert in molecular virology with a strong emphasis on the use of high throughput quantitative proteomics to study viral infections. After his PhD at St Andrews University, he moved to McMaster University in Canada to work on adenovirus based gene therapy. On his return to the UK he secured a highly prestigious MRC scientific training fellowship and a Lectureship at Bristol University where he has published on virus-host cell interactions using high throughput quantitative ‘omics. His latest work has demonstrated how the integration of high throughput transcriptomics and proteomics can be applied to the study of infection and host responses –irrespective of the availability or quality of pre-existing genomic or proteomic data. This approach, known as PIT (proteomics informed by transcriptomics), has been implemented in the popular Galaxy bioinformatics platform, and underpins his current BBSRC research into zoonotic viral infections such as Hendra Virus and MERS.

　　Prof. James Stewart is the Chair of Molecular Virology at the University of Liverpool since 2001. He has an international reputation in the field of virus-host interactions. He is trained as a molecular biologist, applying molecular techniques to study virus/host interactions, specifically the immune response. A large part of his career has been spent studying pathogenesis and virus-host interactions, with a particular focus on the herpesvirus family. One of the most important aspects of his work was establishing the link between active EBV infection and idiopathic pulmonary fibrosis (IPF). He developed murine gammaherpesvirus in mice as a means of studying authentic host-virus interactions, exploiting the power of virus reverse genetics and KO mouse technology.    More recently his research has moved to focus on virus-host interactions in the respiratory tract, using other respiratory pathogens such as influenza A virus and RSV. He has developed an integrative toolkit and pathway with which to do this. He uses conventional and molecular techniques to analyse the course of virus infection combined with big data techniques and informatics to relate the function of viral determinants with host defence responses. The ultimate aim is to translate this into novel diagnostics and interventions.

　　Dr. Regis Stentz is an expert in molecular microbiology who obtained his PhD at the University of Paris VII in 1998. He then moved to the University of Erlangen (Germany), where he developed methods to evaluate RNA aptamer-ligand interactions in vivo as part of an EU TMR fellowship. In 2001, he moved to the Institute of Food Research in Norwich (UK) to study gene transfer in Gram-positive bacteria. He then joined the group of Prof. Simon Carding at the Quadram Institute Bioscience in Norwich and is currently investigating the molecular basis of interactions between the human gut microbiota and the host. To this aim, he is currently developing a novel and exciting research area investigating direct cross-talk between dominant mucosa-associated bacteria and host epithelial cells via outer membrane vesicles produced by the Gram-negative gut commensals Bacteroides.

　　Prof. Hongying Chen obtained her Bsc. (in 1992) and Ph.D (in 1998) in the major of Animal Physiology and Biochemistry in China Agricultural University；participated in the studies on immunological basis for xenotransplantation as a Postdoc in the Institute of Developmental Biology, Chinese Academy of Sciences in 1998-2000; worked on coronaviruses and HIV-1 as a research fellow in the University of Reading, UK in 2000-2009; moved to NWAFU in 2009. Research area: (1) the interaction of animal viruses with their host cells. We investigate the interactions of PRRSV and AcMNPV proteins with their host cell proteins as well as the protein interactions between the viral proteins, using high-throughput proteomics, Yeast two hybridization, fluorescence localization and co-immunoprecipitation.  (2) Optimization of baculovirus expression vector system via knocking out some nonessential genes and inhibiting the apoptosis of insect cells induced by baculovirus infection. Published more than 30 research papers in journals including J Virol, Front. Microbiol. , J proteomics, and Veterinary Microbiology etc.

　　Prof. Tom Wileman trained in cell biology and immunology at Washington University and Harvard Medical Schools in the USA between 1982 and 1994.  His research focussed on the identification of the macrophage mannose endocytosis receptor and the cloning of genes for T-cell antigen receptors.  He was appointed Assistant Professor at Harvard Medical School in 1991.  In 1994 he joined the Pirbright Institute in the UK as Head of Immunology where he studied how viruses such as Foot and Mouth Disease virus and African swine fever virus use cellular organelles to facilitate replication. In 2005 he moved to the University of East Anglia as Professor of Molecular Virology.  He has used infectious bronchitis virus as a model system to study the role played by autophagy in controlling the virus replication.  His is now developing mice with tissue-specific expression of autophagy gene ATG16L1 to study the impact of a new pathway related to autophagy called LC3 associated phagocytosis (LAP), on infection ‘in vivo’.

　　Prof. Simon Carding is Professor of Mucosal Immunology at UEA and Head of the Gut Microbes and Health (GMH) program at the Quadram Institute in Norwich UK.  He trained in cellular and molecular immunology at New York and Yale Universities between 1985 and 1991 and in mucosal immunology and gnotobiology at Univ. Pennsylvania as an Assistant and then Associate Professor prior to returning to the UK in 2000.  His has studied antigen presentation by intestinal epithelial cells particularly their ability to distinguish between different types of commensal bacteria, and to establish a causal link between intestinal inflammation and bone destruction commonly seen in IBD patients. His group has also assigned a unique role to epithelia-associated gamma-delta lymphocytes in maintaining epithelial barrier function and in regulating Paneth cell antimicrobial protein production. More recently, he has developed methods to manipulate commensal Bacteroides strains to generate outer membrane vesicles (OMVs) for use in vaccine delivery.

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